Author/Authors :
Sylvie Ducki، نويسنده , , Richard Forrest، نويسنده , , John A. Hadfield، نويسنده , , Alex Kendall، نويسنده , , Nicholas J. Lawrence، نويسنده , , Alan T. McGown، نويسنده , , David Rennison، نويسنده ,
Abstract :
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3″-Hydroxy-4″-methoxyphenyl)-2-methyl-1-(3′,4′,5′-trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.
