Author/Authors :
Thomas A. Miller، نويسنده , , Prakash R. Vachaspati، نويسنده , , Marc A. Labroli، نويسنده , , Charles D. Thompson، نويسنده , , Amanda L. Bulman، نويسنده , , Timothy L. Macdonald، نويسنده ,
Abstract :
The synthesis and evaluation of azatoxin congeners possessing annealed aromatic frameworks are described. The compounds were evaluated for their abilities to affect topoisomerase II inhibition through the stabilization of “cleavable complex” and for the inhibition of tubulin polymerization using purified bovine brain tubulin.
