Author/Authors :
Mona Patel، نويسنده , , Robert F. Kaltenbach III، نويسنده , , David A. Nugiel، نويسنده , , Robert J. McHugh Jr.، نويسنده , , Prabhakar K. Jadhav، نويسنده , , Lee T. Bacheler، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Susan Erickson-Viitanen، نويسنده , , Sena Garber، نويسنده , , Carol Reid، نويسنده , , Steven P. Seitz، نويسنده ,
Abstract :
Cyclic urea SD146, a potent HIV protease inhibitor bearing a flat resistance profile, possessed poor solubility and bioavailability, which precluded further development of the compound. In an effort to improve upon the pharmacokinetic profile of the compound, several analogs modified at the P1/P1′ residues were prepared and evaluated. Several of those compounds displayed significant improvement of physical properties.
