Title of article :
Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters
Author/Authors :
Stephen T. Schlachter، نويسنده , , Louise A. Galinet، نويسنده , , Sharon K. Shields، نويسنده , , Danielle G. Aspar، نويسنده , , Colin J. Dunn، نويسنده , , Nigel D. Staite، نويسنده , , Richard A. Nugent، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis model, in addition to potent anti-inflammatory effects.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
