Title of article
New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine
Author/Authors
Syed M. Ali Jawaid، نويسنده , , Clark E. Tedford، نويسنده , , Rosilyn Gregory، نويسنده , , Stephen L. Yates، نويسنده , , James G. Phillips، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1133
To page
1138
Abstract
New histamine H3 receptor antagonists were developed using an acetylene moiety as a replacement for the amide-oxime functionality of verongamine 5. Optimization of receptor binding was performed by following aliphatic Topliss tree guidelines. These new H3 ligands demonstrate excellent blood-brain barrier penetration
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789390
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