Title of article
Substrate specificity of human prolyl-4-hydroxylase
Author/Authors
Manish Tandon، نويسنده , , Min Wu، نويسنده , , Tadhg P. Begley and Steven E. Ealick، نويسنده , , Johanna Myllyharju، نويسنده , , Asta Pirskanen and، نويسنده , , Kari Kivirikko، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1139
To page
1144
Abstract
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789391
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