Author/Authors :
Edward S. Lazer، نويسنده , , Ronald Sorcek، نويسنده , , Charles L. Cywin، نويسنده , , Diane Thome، نويسنده , , Genus J. Possanza، نويسنده , , Anne G. Graham، نويسنده , , Laurie Churchill، نويسنده ,
Abstract :
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
