UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): Promising step in prediction of oligonucleotide analog properties?

The isopolar nonisosteric phosphonate analogs of ApA differing in the position of extra methylene group introduced into the sugar-phosphate backbone, featuring both possible 2′,5′- and 3′,5′- pairs as well as their conformationally restricted congeners, were investigated for their ability to form complexes with polyU. The results may lead to the specification of candidates for synthesis of novel oligonucleotides.