Title of article
Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones
Author/Authors
D. Mark Gleave، نويسنده , , Steven J. Brickner، نويسنده , , Peter R. Manninen، نويسنده , , Debra A. Allwine، نويسنده , , Kristine D. Lovasz، نويسنده , , Douglas C. Rohrer، نويسنده , , John A. Tucker، نويسنده , , Gary E. Zurenko، نويسنده , , Charles W. Ford، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1231
To page
1236
Abstract
A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789409
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