Title of article
Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis-sulfonamide dihydropyrones
Author/Authors
Musiri N. Janakiraman، نويسنده , , Keith D. Watenpaugh، نويسنده , , Paul K. Tomich، نويسنده , , Kong Teck Chong، نويسنده , , Steve R. Turner، نويسنده , , Ruben A. Tommasi، نويسنده , , Suvit Thaisrivongs، نويسنده , , Joseph W. Strohbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1237
To page
1242
Abstract
Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-related sulfonamide group. Selected bis-sulfonamide dihydropyrone analogues display high HIV protease inhibitory activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789410
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