Author/Authors :
Nicholas J. S. Harmat، نويسنده , , Cristina Di Bugno، نويسنده , , M. Criscuoli، نويسنده , , Raffaello Giorgi، نويسنده , , Annalisa Lippi، نويسنده , , Adriano Martinelli، نويسنده , , Susanna Monti، نويسنده , , A. Subissi، نويسنده ,
Abstract :
A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.
