Title of article
New synthetic inhibitors of microtubule depolymerization
Author/Authors
Ulrich Klar، نويسنده , , Hermann Graf، نويسنده , , Oliver Schenk ، نويسنده , , Bodo R?hr، نويسنده , , Horst Schulz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1397
To page
1402
Abstract
A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789441
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