Author/Authors :
Bruno Bellier، نويسنده , , Sophie Da Nascimento، نويسنده , , Hervé Meudal، نويسنده , , Edith Gincel، نويسنده , , Bernard P. Roques، نويسنده , , Christiane Garbay، نويسنده ,
Abstract :
A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists.
