Author/Authors :
Khaled J. Barakat، نويسنده , , Kang Cheng، نويسنده , , Wanda W. -S. Chan، نويسنده , , Bridget S. Butler، نويسنده , , Thomas M. Jacks، نويسنده , , Klaus D. Schleim، نويسنده , , Donald F. Hora Jr.، نويسنده , , Gerard J. Hickey، نويسنده , , Roy G. Smith، نويسنده , , Arthur A. Patchett، نويسنده , , Ravi P. Nargund، نويسنده ,
Abstract :
A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC50 = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.
