Author/Authors :
Tohru Tanami، نويسنده , , Kazuya Kameo، نويسنده , , Naoya Ono، نويسنده , , Takashi Nakagawa، نويسنده , , Shigesato Annou، نويسنده , , Mie Tsuboi، نويسنده , , Kousuke Tani، نويسنده , , Sentaro Okamoto، نويسنده , , Fumie Sato، نويسنده ,
Abstract :
13-Dehydro derivatives of prostaglandin E1, E2, E3, F1α and F2α were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.
