Novel antitumor 5,10-dihydro-5,10-dioxo-1H-benzo[g]isochromene-3-carboxamides were discovered.

Asymmetric synthesis of -carbocyclic 2′,3′-didehydro-2′,3′-dideoxyadenosine and its analogs were accomplished and their anti-HIV activities were evaluated. It was found that -carbocyclic 2′,3′-didehydro-2′,3′-dideoxyadenosine exhibited moderately potent anti-HIV (EC50 = 2.4 μM) activity in human PBM cells without cytotoxicity up to 100 μM.