Title of article
Novel modified tripeptide inhibitors of α4β7 mediated lymphoid cell adhesion to MAdCAM-1
Author/Authors
H. N. Shroff، نويسنده , , C. F. Schwender، نويسنده , , A. D. Baxter، نويسنده , , F. Brookfield، نويسنده , , L. J. Payne، نويسنده , , N. A. Cochran، نويسنده , , D. L. Gallant، نويسنده , , M. J. Briskin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1601
To page
1606
Abstract
MAdCAM-1 specifically binds the lymphocyte integrin α4β7 and participates in the homing of leukocytes to intestinal mucosal sites. The LDT sequence located on the CD loop of MAdCAM-1 is an important binding site for MAdCAM-1/α4β7 interactions. N-Terminus acylation of the LDT motif and modification of the C-terminus carboxamide with amines led to low micromolar MAdCAM-1 inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789480
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