Author/Authors :
Stephen A. Hermitage، نويسنده , , Alison Murphy، نويسنده , , Stanley M. Roberts، نويسنده ,
Abstract :
Lactones 2 and 7 were synthesised and tested against six human tumour cell lines (Pancreas-a, BXPC-3), (Thyroid ca, KAT-4), (Thyroid ca, SW1736), (Lung-NSC, NCI-H460), (Pharynx-sq, FADU) and (Prostate, DU-145). Lactone 7 proved inactive, but lactone 2 displayed some activity against four of the six cell lines examined. Both lactones were converted into an intermediate 5en route to Altohyrtin A.
