Korundamine A, a novel HIV-inhibitory and antimalarial “hybrid” naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis

A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first “hybrid” dimer found in the Ancistrocladaceae; , it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.