Title of article
Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents
Author/Authors
Douglas G. Batt، نويسنده , , Joseph J. Petraitis، نويسنده , , Susan R. Sherk، نويسنده , , Robert A. Copeland، نويسنده , , Randine L. Dowling، نويسنده , , Tracy L. Taylor، نويسنده , , Elizabeth A. Jones، نويسنده , , Ronald L. Magolda، نويسنده , , Bruce D. Jaffee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1745
To page
1750
Abstract
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789509
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