Title of article
Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity
Author/Authors
Yoshiki Yoshida، نويسنده , , J. DAVID BARRETT، نويسنده , , Hidenori Azami، نويسنده , , Chizu Morinaga، نويسنده , , Yoshimi Matsumoto، نويسنده , , Hisashi Takasugi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1897
To page
1902
Abstract
The synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3-acetamido-2,6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram-positive and Gram-negative bacteria.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789540
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