Author/Authors :
Dennis J. Hlasta، نويسنده , , James P. Demers، نويسنده , , Barbara D. Foleno، نويسنده , , Stephanie A. Fraga-Spano، نويسنده , , Jihua Guan، نويسنده , , Jamese J. Hilliard، نويسنده , , Mark J. Macielag، نويسنده , , Kwasi A. Ohemeng، نويسنده , , Cheryl M. Sheppard، نويسنده , , Zhihua Sui، نويسنده , , Glenda C. Webb، نويسنده , , Michele A. Weidner-Wells، نويسنده , , Harvey Werblood، نويسنده , , John F. Barrett، نويسنده ,
Abstract :
This SAR study has shown that the salicylanilide is the pharmacophore for inhibition of the bacterial two-component system. Hydrophobic substituents improve the potency of inhibitors in this series; however, hydrophobicity is not the sole determinant for inhibition; structural and electronic requirements also exist. Closantel (1) was found to inhibit a two-component system and to have antibacterial activity against drug resistant S. aureus and E. faecium.
