Author/Authors :
Qun Li ، نويسنده , , Weibo Wang، نويسنده , , Kristine B. Berst، نويسنده , , Akiyo Claiborne، نويسنده , , Lisa Hasvold، نويسنده , , Kathleen Raye، نويسنده , , Michael Tufano، نويسنده , , Angela Nilius، نويسنده , , Linus L. Shen، نويسنده , , Robert Flamm، نويسنده , , Jeff Alder، نويسنده , , Kennan Marsh، نويسنده , , DeAnne Crowell، نويسنده , , Daniel T. W. Chu، نويسنده , , Jacob J. Plattner، نويسنده ,
Abstract :
The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.
