Title of article
Halohydrin analogues of cryptophycin 1: Synthesis and biological activity
Author/Authors
Gunda I. Georg، نويسنده , , Syed M. Ali Jawaid، نويسنده , , Valentino J. Stella، نويسنده , , Wanda N. Waugh، نويسنده , , Richard H. Himes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
1959
To page
1962
Abstract
The chloro-, bromo-, and iodo-derivatives 2–4 of the antimitotic drug cryptophycin 1 were synthesized by opening the epoxide ring. The biological activities of the compounds were tested in an in vitro microtubule assembly and a cell proliferation assay. The chloro-derivative 2 showed lower activity in the tubulin assay compared to 3 and 4, but they all showed similar inhibition in the proliferation assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789551
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