Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation

We have synthesized and studied the effects of phosphorothioate (PS) oligodeoxyribonucleotide (DNA) and oligoribonucleotides (RNA, 2′-O-methyl-RNA and 2′-5′-RNA) on complement activation and prolongation of activated partial thromboplastin time (aPTT) in vitro. These results suggest that a PS-DNA prolongs aPTT, and inhibits complement lysis more than do the PS-RNA analogs.