Title of article
Novel H3 receptor antagonists. Sulfonamide homologs of histamine
Author/Authors
Ronald Wolin، نويسنده , , Michael Connolly، نويسنده , , Adriano Afonso، نويسنده , , John A. Hey، نويسنده , , Hoyan She، نويسنده , , Maria A. Rivelli، نويسنده , , Shirley M. Willams، نويسنده , , Robert E. West Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2157
To page
2162
Abstract
Sulfonamides derived from 4(5)-(ω-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding affinities were considerably weaker in the propyl series. Separation of the imidazole ring and the sulfonamide unit by a four- or five-carbon tether afforded potent H3 receptor antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789589
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