Author/Authors :
Ronald Wolin، نويسنده , , Michael Connolly، نويسنده , , Adriano Afonso، نويسنده , , John A. Hey، نويسنده , , Hoyan She، نويسنده , , Maria A. Rivelli، نويسنده , , Shirley M. Willams، نويسنده , , Robert E. West Jr.، نويسنده ,
Abstract :
Sulfonamides derived from 4(5)-(ω-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding affinities were considerably weaker in the propyl series. Separation of the imidazole ring and the sulfonamide unit by a four- or five-carbon tether afforded potent H3 receptor antagonists.
