Author/Authors :
Nobuhiro Sakurai، نويسنده , , Mitsuharu Sano، نويسنده , , Fumihiro Hirayama، نويسنده , , Tsuyoshi Kuroda، نويسنده , , Satoru Uemori، نويسنده , , Akihiko Moriguchi، نويسنده , , Katsuhiro Yamamoto، نويسنده , , Yoshifumi Ikeda، نويسنده , , Takeshi Kawakita، نويسنده ,
Abstract :
A series of the titled compounds was synthesized and tested for anti- Helicobacter pylori activities. We discovered Y-34867 having the most potent activity against Helicobacter pylori among the quinolones tested along with high photostability. Furthermore, Y-34867 showed an excellent therapeutic effect in the experimental Helicobacter pylori infected Mongolian gerbil model.
