Title of article
Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis
Author/Authors
Ashok Bhandari، نويسنده , , David G. Jones، نويسنده , , John R. Schullek، نويسنده , , Kham Vo، نويسنده , , Caryn A. Schunk، نويسنده , , Lisa L. Tamanaha، نويسنده , , Dawn Chen، نويسنده , , Zhengyu Yuan، نويسنده , , Michael C. Needels، نويسنده , , Mark A. Gallop، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2303
To page
2308
Abstract
Phosphomannose Isomerase (PMI) has been shown by genetic methods to be an essential enzyme in fungal cell wall biosynthesis. The PMI inhibitor AF14049 was discovered as an unanticipated side product from high-throughput library screening against the enzyme from C. albicans. Solid-phase synthetic methods were developed and a series of libraries and discrete analogs synthesized to explore SAR around AF14049.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789616
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