Title of article
Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers
Author/Authors
Po-Wai Yuen، نويسنده , , Robert M. Schelkun، نويسنده , , Balazs Szoke، نويسنده , , Katalin Tarczy-Hornoch، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2415
To page
2418
Abstract
Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACCʹs have been identified. Their synthesis and preliminary pharmacology are discussed herein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789636
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