Author/Authors :
Kiyoshi Tsuji، نويسنده , , Takashi Ogino، نويسنده , , Nobuo Seki، نويسنده , , Masae Sawada، نويسنده , , Yu Sudo، نويسنده , , Fusako Nishigaki، نويسنده , , Toshitaka Manda، نويسنده , , Massaki Matsuo، نويسنده ,
Abstract :
5-(2-Pyridylsulfonyl)-2-thiazolamine (2) was effective both in mitomycin C (MMC)-induced thrombocytopenia and in an animal model of idiopathic thrombocytopenic purpura (ITP). It also suppressed the increase of autoantibodies against platelets in the ITP model and showed no blood toxicity. Chemical modification of 2 led to the discovery of more potent compounds against MMC-induced thrombocytopenia.
