Title of article
Synthesis and binding of stable bisubstrate ligands for phosphoglycerate kinase
Author/Authors
David M. Williams، نويسنده , , David L. Jakeman، نويسنده , , Joseph S. Vyle، نويسنده , , Michael P. Williamson، نويسنده , , G. Michael Blackburn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2603
To page
2608
Abstract
Stable bisubstrate ligands of phosphoglycerate kinase (PGK) have been synthesised with AMP or ADP conjugated to hydrolytically-stable, symmetrical analogues of 1,3-bisphosphoglycerate and their binding to yeast PGK evaluated. Their Kds decrease with net negative charge, with a penta-anionic analogue 7 showing highest affinity - in accordance with its approximation to the transition state for the reaction catalysed by PGK.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789673
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