Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues
Author/Authors :
Jackie A. Highfield، نويسنده , , Lina K. Mehta، نويسنده , , John Parrick، نويسنده , , Luis P. Candeias، نويسنده , , Peter Wardman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
2609
To page :
2614
Abstract :
Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of Fe(II) and dioxygen by both the prodrugs and the activated products are determined and their in vitro cytotoxicity measured.
