Author/Authors :
J. Milton، نويسنده , , M. J. Slater، نويسنده , , A. J. Bird، نويسنده , , D. Spinks، نويسنده , , G. Scott، نويسنده , , C. E. Price، نويسنده , , Leon S. Downing، نويسنده , , D. V. S. Green، نويسنده , , S. Madar، نويسنده , , R. Bethell، نويسنده , , D. K. Stammers، نويسنده ,
Abstract :
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50s in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.
