Title of article :
Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines
Author/Authors :
Lawrence G. Hamann، نويسنده , , David T. Winn، نويسنده , , Charlotte L. F. Pooley، نويسنده , , Christopher M. Tegley، نويسنده , , Sarah J. West، نويسنده , , Luc. J. Farmer، نويسنده , , Lin Zhi، نويسنده , , James P. Edwards، نويسنده , , Keith B. Marschke، نويسنده , , Dale E. Mais، نويسنده , , Mark E. Goldman، نويسنده , , Todd K. Jones، نويسنده ,
Abstract :
A series of nonsteroidal human progesterone receptor (hPR) antagonists based on conformationally-restricted analogues of a 6-aryl-1,2-dihydro-2,2,4-trimethylquinoline pharmacophore were synthesized and evaluated for their ability to bind to the human progesterone receptor and inhibit progesterone-stimulated reporter gene expression in mammalian cells.
