Title of article :
Synthesis and cytotoxicity of acetyl-4H, 9H-naphtho[2,3-b]thiophene-4,9-diones
Author/Authors :
Li-Jiau Huang، نويسنده , , Sheng-Chu Kuo، نويسنده , , Cherng-Yih Perng، نويسنده , , Yu-Hua Chao، نويسنده , , Tian-Shung Wu، نويسنده , , Andrew T. McPhail، نويسنده , , Anthony Mauger، نويسنده , , Huey-Hwa Cheng، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
Several new acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones were synthesized and evaluated for in vitro cytotoxicity by NCI against seven cancer cell types. 2,7-Diacetyl naphtho[2,3-b]thiophene-4,9-dione (9) showed significant cytotoxicity against leukemia cells with log GI50 values of −7.61 against SR cells and −7.18 against MOLT-4 cells. 3-Acetyl-naphtho[2,3-b]thiophene-4,9-dione (6) also demonstrated potent cytotoxicity in the latter cell line with log GI50< −8
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
