Title of article
Quinazolines: Combined type 3 and 4 phosphodiesterase inhibitors
Author/Authors
Brigitte Charpiot، نويسنده , , Jvan Brun، نويسنده , , Irene Donze، نويسنده , , Reto Naef، نويسنده , , Monique Stefani، نويسنده , , Thomas Mueller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2891
To page
2896
Abstract
A series of quinazolines has been prepared and evaluated for its ability to inhibit cyclic AMP phosphodiesterase type 3, type 4A, 4B and 4D. The most potent inhibitors showed IC50 values in the nanomolar range for type 3 and type 4 isoforms and bind with high affinity to the [3H]rolipram binding site. These quinazolines represent a new family of potent mixed PDE 3/4 inhibitors and are expected to have a therapeutic potential.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789727
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