Title of article
First synthesis of alternating SATE-phosphotriester/ phosphodiester prooligonucleotides on solid support
Author/Authors
Guilhem Tosquellas، نويسنده , , Jean Charles Bologna، نويسنده , , François Morvan، نويسنده , , Bernard Rayner، نويسنده , , Jean-Louis Imbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2913
To page
2918
Abstract
Prooligonucleotides with alternating S-Acyl-ThioEthyl (SATE) phosphotriester and phosphodiester linkages or a gap were synthesized by elimination of cyanoethyl group with non-nucleophilic base DBU. Their half-lives in the presence of Pig Liver Esterases (PLE) and in total cell extract were determined.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789731
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