Conformationally constrained no synthase inhibitors: Rigid analogs of L-N-iminoethylornithine
Author/Authors :
Jacques Eustache، نويسنده , , Alfred Grob، نويسنده , , Charles Lam، نويسنده , , Odile Sellier، نويسنده , , Gerhard Schulz، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
2961
To page :
2966
Abstract :
The synthesis of eight rigid analogs of L-N-iminoethylomithine (L-NIO) is described. The compounds have been evaluated for their inhibition of inducible nitric oxide synthase. Preliminary structure-activity relationships are discussed.
