Author/Authors :
Koichiro Morihira، نويسنده , , Toshiyuki Nishimori، نويسنده , , Hiroyuki Kusama، نويسنده , , Yoshiaki Horiguchi، نويسنده , , Isao Kuwajima، نويسنده , , Takashi Tsuruo، نويسنده ,
Abstract :
The C-aromatic taxoids were synthesized to develop effective inhibitors againts drug efflux mediated by p-glycoproteins. Among those tested using multi-drug resistant tumor cells (2780AD), the benzoate 11 exhibited significant activity as potent as verapamil, a well-established MDR reversing agent.
