Title of article
Macrolide biosynthesis: A single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae
Author/Authors
Edmund I. Graziani، نويسنده , , David E. Cane، نويسنده , , Melanie C. Betlach، نويسنده , , James T. Kealey، نويسنده , , Robert McDaniel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3117
To page
3120
Abstract
The final step in the biosynthesis of methymycin, neomethymycin, and picromycin is an hydroxylation, shown to be carried out by the cytochrome P-450 monooxygenase, PicK. Direct comparison of the relative kcat/Km values for the two substrates, YC-17 and narbomycin, showed a threefold rate preference of picK for narbomycin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789771
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