Title of article
Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase
Author/Authors
Amos B. Smith III، نويسنده , , Setsuya Sasho، نويسنده , , Bari A. Barwis، نويسنده , , Paul Sprengeler، نويسنده , , Joseph Barbosa، نويسنده , , Ralph Hirschmann، نويسنده , , Barry S. Cooperman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3133
To page
3136
Abstract
A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789774
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