Author/Authors :
Amos B. Smith III، نويسنده , , Setsuya Sasho، نويسنده , , Bari A. Barwis، نويسنده , , Paul Sprengeler، نويسنده , , Joseph Barbosa، نويسنده , , Ralph Hirschmann، نويسنده , , Barry S. Cooperman، نويسنده ,
Abstract :
A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
