Title of article
Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa
Author/Authors
John M. Fevig، نويسنده , , Joseph Cacciola، نويسنده , , Richard S. Alexander، نويسنده , , Robert M. Knabb، نويسنده , , Gilbert N. Lam، نويسنده , , Pancras C. Wong، نويسنده , , Ruth R. Wexler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
3143
To page
3148
Abstract
The serine protease factor Xa is a critical enzyme in the blood coagulation cascade. Recently, the inhibition of factor Xa has begun to emerge as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe a series of meta-amidino-N,N-disubstituted anilines as structurally simple and very potent inhibitors of factor Xa.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789776
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