Title of article
Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications
Author/Authors
Yves St-Denis، نويسنده , , Corinne E. Augelli-Szafran، نويسنده , , Benoit Bachand، نويسنده , , Kent A. Berryman، نويسنده , , John DiMaio، نويسنده , , Annette M. Doherty، نويسنده , , Jeremy J. Edmunds، نويسنده , , Lorraine Leblond، نويسنده , , Sophie Lévesque، نويسنده , , Lakshmi S. Narasimhan، نويسنده , , Jan R. Penvose-Yi، نويسنده , , J. Ronald Rubin، نويسنده , , Micheline Tarazi، نويسنده , , Peter D. Winocour، نويسنده , , M. Arshad Siddiqui، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
3193
To page
3198
Abstract
Peptidomimetic inhibitors of general structure 1 have been prepared. Optimization of the binding affinities of these compounds through variation of the P3 hydrophobic residue is described. Selected substituted bicylic lactams displayed interesting pharmacological profiles both in vitro and in vivo.
Abstract
Design, synthesis, and SAR of low molecular weight peptidomimetic inhibitors of thrombin are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789785
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