Author/Authors :
Edmond Bacher، نويسنده , , Christiene Boer، نويسنده , , Katharine Bray-French، نويسنده , , F. W. Joachim Demnitz، نويسنده , , Thomas H. Keller، نويسنده , , Lazzaro Mazzoni، نويسنده , , Thomas Müller، نويسنده , , Christoph Walker، نويسنده ,
Abstract :
Derivatization of rolipram led to the identification of 3-[4-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidin-1-yl]-5-(3-methoxybenzyloxy)-benzoic acid N′,N′-dimethylhydrazide ( ), a potent and selective inhibitor of PDE4, which inhibits the activation of human leukocytes with pIC50 values in the range of 7.3 – 7.8, and blocks antigen induced eosinophilia in Brown Norway rats at a dose of 1 mg/kg (i.t.).
