Author/Authors :
Takashi Takahashi، نويسنده , , Hiroshi Tanaka ، نويسنده , , Akihisa Matsuda، نويسنده , , Takayuki Doi، نويسنده , , Haruo Yamada، نويسنده , , Takuyuki Matsumoto، نويسنده , , Daisuke Sasaki، نويسنده , , Yukio Sugiura، نويسنده ,
Abstract :
The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage
