Title of article
Potent, non-thiol inhibitors of farnesyltransferase
Author/Authors
Michael J. Breslin، نويسنده , , S. Jane deSolms، نويسنده , , Elizabeth A. Giuliani، نويسنده , , Gerald E. Stokker، نويسنده , , Samuel L. Graham، نويسنده , , David L. Pompliano، نويسنده , , Scott D. Mosser، نويسنده , , Kelly A. Hamilton، نويسنده , , John H. Hutchinson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
3311
To page
3316
Abstract
The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain a substituted phenyl group at the N terminus, which may occupy a novel binding domain on the Ras protein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789809
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