Title of article
Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity
Author/Authors
Toshihiro Hatanaka، نويسنده , , Koichi Fujita، نويسنده , , Koji Ohsumi، نويسنده , , Ryusuke Nakagawa، نويسنده , , Yumiko Fukuda، نويسنده , , Yukio Nihei، نويسنده , , Yasuyo Suga، نويسنده , , Yukio Akiyama، نويسنده , , Takashi Tsuji، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3371
To page
3374
Abstract
A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789820
Link To Document