Title of article
4,4,14α-trimethyl 9β,19-cyclo-5α-26-homocholesta-24,26-dien-3β-ol: a potent mechanism-based inactivator of Δ24(25)- to Δ25(27)-sterol methyl transferase
Author/Authors
W. David Nes، نويسنده , , Ling He، نويسنده , , Anil T. Mangla، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3449
To page
3452
Abstract
The title compound (4A) was synthesized and tested as a mechanism-based inactivator of the sterol methyl transferase (SMT) enzyme from Prototheca wickerhamii. Using cycloartenol as substrate, 4A was found to exhibit time-dependent inactivation kinetics, generating a Ki value of 30 μM and Kinact value of 0.30 min−1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789835
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