Title of article
Novel cytotoxic diterpenes from the stem of dysoxylum kuskusense
Author/Authors
Toshihiro Fujioka، نويسنده , , Miyako Yamamoto، نويسنده , , Yoshiki Kashiwada، نويسنده , , Hiroko Fujii، نويسنده , , Kunihide Mihashi، نويسنده , , Yasumasa Ikeshiro، نويسنده , , Ih-Sheng Chen، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
3479
To page
3482
Abstract
Three novel diterpenes, dysokusones A (1), B (2), and C (3), were isolated from the stem of Dysoxylum kuskusense as cytotoxic substances. The structures were established by spectroscopic examinations. Compounds 1, 2, and 3 were cytotoxic toward HL-60(TB) cells with EC50 values of 2.25, 6.35, and 2.37 μM, respectively. Compound 1 also displayed cytotoxicity against K-562 and NCI-H522 cells with EC50 values of 5.04 and 4.80 μM, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789841
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