Author/Authors :
Francesco G. Salituro، نويسنده , , Christopher T. Baker، نويسنده , , John J. Court، نويسنده , , David D. Deininger، نويسنده , , Eunice E. Kim، نويسنده , , Biquin Li، نويسنده , , Perry M. Novak، نويسنده , , Bhisetti G. Rao، نويسنده , , S. Pazhanisamy، نويسنده , , Margaret D. Porter، نويسنده , , Wayne C. Schairer، نويسنده , , Roger D. Tung، نويسنده ,
Abstract :
A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3–7 were designed, synthesized, and found to be potent inhibitors of HIV protease.
